Eleven year-old Akeelah Anderson's life is not easy: her father is dead, her mom ignores her, her brother runs with the local gangbangers. She's smart, but her environment threatens to strangle her aspirations. Responding to a threat by her school's principal, Akeelah participates in a spelling bee to avoid detention for her many absences. Much to her surprise and embarrassment, she wins. Her principal asks her to seek coaching from an English professor named Dr. Larabee for the more prestigious regional bee. As the possibility of making it all the way to the Scripps National Spelling Bee looms, Akeelah could provide her community with someone to rally around and be proud of -- but only if she can overcome her insecurities and her distracting home life. She also must get past Dr. Larabee's demons, and a field of more experienced and privileged fellow spellers.

A team of trainees of the National Guard brings supply to the New Mexico Desert for a group of soldiers and scientists that are installing a monitoring system in Sector 16. They do not find anybody in the camp, and they receive a blurred distress signal from the hills. Their sergeant gathers a rescue team, and they are attacked and trapped by deformed cannibals, having to fight to survive.